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HER-2/neu癌基因在许多肿瘤,如乳腺癌、卵巢癌、非小细胞肺癌等肿瘤中高表达,在肿瘤的发生与发展中起重要作用,与肿瘤的转化、转移、复发、预后差、患者生存期缩短有关。HER-2/neu在乳腺癌过度表达率约为20%～30%,编码蛋白P185HER2属生长因子受体家族,抗P185HER2单克隆抗体(Herceptin)作为靶向药物已临床应用治疗HER2/neu高表达乳腺癌。
HER-2 / neu oncogene is highly expressed in many tumors such as breast cancer, ovarian cancer and non-small cell lung cancer and plays an important role in the occurrence and development of cancer. It is associated with tumor transformation, metastasis, recurrence, poor prognosis, Patients with shortened survival. The overexpression rate of HER-2 / neu in breast cancer is about 20% -30%. The gene encoding P185HER2 is a growth factor receptor family, and the anti-P185HER2 monoclonal antibody (Herceptin) as a target drug has been clinically applied to treat HER2 / neu overexpression Breast cancer.