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目的:探讨冠心病(CHD)者血中血小板活化、凝血、纤溶指标变化及其意义。方法:对145例CHD患者和40例正常对照者血小板α-颗粒膜糖蛋白-140(GMP-140)、组织因子(TF)、纤维蛋白原(Fib)及D-二聚体水平进行测定、分析。结果:急性心肌梗死组、不稳定心绞痛组以及冠状动脉存在2支及2支以上病变患者的GMP-140、TF、Fib及D-二聚体水平均显著高于正常对照组的(P<0.05);稳定心绞痛组TF和Fib水平均显著高于正常对照组的(P<0.05)。结论:GMP-140、TF、Fib及D-二聚体水平与CHD病情相关。检测GMP-140、TF、Fib及D-二聚体水平,对CHD的诊断和病情监测有一定价值。
Objective: To investigate the changes of platelet activation, coagulation and fibrinolysis in blood of patients with coronary heart disease (CHD) and its significance. Methods: The levels of GMP-140, TF, Fib and D-dimer were measured in 145 CHD patients and 40 normal controls. analysis. Results: The levels of GMP-140, TF, Fib and D-dimer in acute myocardial infarction group, unstable angina pectoris group and coronary artery with 2 or more lesions were significantly higher than those in normal control group (P <0.05 ). The levels of TF and Fib in stable angina group were significantly higher than those in normal control group (P <0.05). Conclusion: The levels of GMP-140, TF, Fib and D-dimer are correlated with CHD. Detection of GMP-140, TF, Fib and D-dimer levels, the diagnosis of CHD and disease monitoring have some value.