论文部分内容阅读
目的了解不同体质指数(BMI)的2型糖尿病(T2DM)患者的血管性血友病因子(vWF)水平以及胰岛素抵抗(IR)程度。方法依据BMI将134例T2DM患者分为正常体重组(50例)、超重组(50例)与肥胖组(34例),分别测定血浆vWF水平,并评估、比较各组IR程度。结果肥胖组的vWF水平、HOMA-IR高于正常体重组(P<0.05);各组间胰岛素作用指数(IAI)及定量胰岛素敏感性指数(QUICKI)有统计学差异(P<0.05);HOMA IR、IAI及QUICKI各指标间呈正相关。结论肥胖的T2DM患者血浆vWF水平升高、IR程度明显加重。
Objective To investigate the levels of von Willebrand factor (vWF) and insulin resistance (IR) in type 2 diabetes mellitus (T2DM) with different body mass index (BMI). Methods According to BMI, 134 patients with T2DM were divided into normal weight group (50 cases), overweight group (50 cases) and obesity group (34 cases). Plasma vWF levels were measured and compared. Results The levels of vWF and HOMA-IR in obese group were significantly higher than those in normal weight group (P <0.05). The IAI and QUICKI in each group were significantly different (P <0.05). HOMA IR, IAI and QUICKI indicators were positively correlated. Conclusion Plasma vWF level is elevated in obese T2DM patients and the degree of IR is significantly increased.