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目的：探讨中医内治类风湿性关节炎(RA)的疗效。方法：选取 Wistar 大鼠36只，雌雄各半，按性别体 重分层后，随机分4组(乌头汤组、雷公藤组、生理盐水组、正常对照组)，注射弗氏完全佐剂制备佐剂性关节炎模 型。模型制备后第8d 给药，连续至第28d，1次/d，观察其对 RA 大鼠血清中一氧化氮(NO)、肿瘤坏死因子α(TNF α)含量及足部肿胀度的影响。结果：乌头汤能抑制佐剂性注射对侧足的肿胀，降低 RA 大鼠血清中 NO、TNFα的含 量。有助于恢复免疫稳定状态。其作用优于雷公藤多苷片。(P＜0． 05) 。结论：乌头汤具有较强的抗炎消肿作用， 内治类风湿效果满意。
Objective: To explore the efficacy of Chinese medicine in the treatment of rheumatoid arthritis (RA). METHODS: Thirty-six Wistar rats, male and female, were randomly divided into 4 groups (Wutoutang group, Tripterygium wilfordii group, normal saline group, and normal control group) and stratified by gender. The injections of Freund’s complete adjuvant were prepared. Adjuvant arthritis model. At the 8th day after the preparation of the model, it was continued to the 28th day, once a day, to observe the effect of RA on rat serum nitric oxide (NO), tumor necrosis factor α (TNF α) content and foot swelling degree. Results: Wutou Decoction can inhibit the swelling of lateral foot by adjuvant injection and reduce the content of NO and TNFα in serum of RA rats. Helps restore immune stability. Its role is better than Tripterygium polyglycoside tablets. (P<0.05). Conclusion: Wutou Decoction has strong anti-inflammatory and swelling effect, and the effect of internal treatment of rheumatoid is satisfactory.