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将离子液体(1-丁基-3甲基咪唑六氟磷酸盐,[Bmim][PF6])与石墨粉混合,制备了离子液体修饰碳糊电极(CILE),在0.1mol/L NH3-NH4Cl盐缓冲溶液中(pH9.0),采用循环伏安法(CV),研究了尼群地平在不同电极上的电化学行为,建立了CILE测定尼群地平的电化学方法.结果表明,在0.1V/s扫速下,尼群地平的氧化还原峰电位差(ΔEP)为53mV.尼群地平的氧化峰电流与其浓度在1.0~200μmol/L范围内呈线性关系(r=0.990 1),检出限为0.3μmol/L(S/N=3).该修饰电极成功用于片剂中尼群地平含量的测定,且其电子转移速率、重复性和灵敏度优于传统碳糊电极,但存在较大的背景电流.
An ionic liquid modified carbon paste electrode (CILE) was prepared by mixing ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate [Bmim] [PF6]) with graphite powder. The electrochemical behavior of nitrendipine on different electrodes was investigated by cyclic voltammetry (CV) in salt buffer solution (pH 9.0). The electrochemical method for the determination of nitrendipine by CILE was established. The results showed that at 0.1 The potential difference (ΔEP) of redox peak of nitrendipine was 53 mV at V / s scan rate.The oxidation peak current of nitrendipine was linear with the concentration range of 1.0-200 μmol / L (r = 0.990 1) (S / N = 3) .The modified electrode was successfully used in the determination of nitrendipine tablets, and its electron transfer rate, repeatability and sensitivity than the traditional carbon paste electrode, but there Large background current.