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目的观察中药联合DA化疗方案治疗老年急性髓系白血病患者的疗效及安全性。方法老年急性髓系白血病患者86例分为两组:C组40例,予常规DA化疗方案(阿糖胞苷+柔红霉素)静脉滴注治疗;A组46例,加用益气健脾补肾汤内服治疗。比较化疗2个疗程的临床疗效、骨髓抑制及不良反应发生情况。结果 A、C组临床总有效率相仿(87.0%vs.82.5%)(P>0.05)。A组治疗1、7、14d时的Hb、WBC和Plt均低于C组(P<0.05)。A组不良反应发生率低于C组(P<0.05)。结论中药联合DA化疗方案治疗老年急性髓系白血病疗效较单用DA化疗方案好,不良反应少。
Objective To observe the efficacy and safety of traditional Chinese medicine combined with DA chemotherapy in the treatment of elderly patients with acute myeloid leukemia. Methods A total of 86 elderly patients with acute myeloid leukemia were divided into two groups: 40 cases in group C, treated with routine chemotherapy regimen (cytarabine + daunorubicin) by intravenous drip. Group A (n = 46) Bushen decoction treatment. Compare the two courses of chemotherapy clinical efficacy, bone marrow suppression and adverse reactions. Results The total clinical effective rates in groups A and C were similar (87.0% vs. 82.5%) (P> 0.05). The levels of Hb, WBC and Plt in group A were lower than those in group C on days 1,7 and 14 (P <0.05). The incidence of adverse reactions in group A was lower than that in group C (P <0.05). Conclusion Chinese medicine combined with DA chemotherapy regimen for the treatment of acute myeloid leukemia in elderly patients with DA than chemotherapy alone, adverse reactions.