阻断乙型肝炎病毒母婴传播的临床研究

• 作 者: 李顺英 李小敏 谭忠伟 陈芝菊
• 机 构: 广东省江门市妇幼保健院,广东省江门市妇幼保健院,广东省江门市妇幼保健院,广东省江门市妇幼保健院 529000,529000,529000,529000
• 出 处: 中国实用妇科与产科杂志
• 发表日期: 2004年09期
• 关键词: 乙型肝炎病毒 乙型肝炎免疫球蛋白 DNA 妊娠

目的　探讨乙型肝炎病毒 (HBV)母婴传播的途径及阻断措施。方法　对 2 0 0 2年 6月至 2 0 0 3年 6月广东省江门市妇幼保健院 2 5 6 8例孕妇孕期筛查HBV标志物HBVM ,对HBsAg(+)孕妇检测HBVDNA ,并于妊娠 16～ 2 0周每月注射乙型肝炎免疫球蛋白 (HBIG) ,采用择期剖宫产术终止妊娠 ,新生儿检测HBVM ,并联合免疫注射HBIG及乙型肝炎疫苗 ,检测产妇乳汁HBVDNA ,阳性者采用人工喂养婴儿。结果　筛查孕妇 2 5 6 8例 ,HBsAg(+)者 318例 ,占 12 38%。新生儿HBsAg(+)者 10例 ,占 3 14 % ,新生儿 1个月时复测无新增病例 ,多种措施联合阻断成功率达 96 86 %。结论　孕妇早期检测HBVM、HBVDNA ,早诊断 ,早治疗 ,多种措施干预 ,可有效阻断乙型肝炎病毒母婴传播

Objective To explore the ways of mother-to-child transmission of hepatitis B virus (HBV) and its blocking measures. Methods From June 2002 to June 2003, 2568 pregnant women in Maternal and Child Health Care Hospital of Jiangmen City, Guangdong Province were screened for HBVM during pregnancy and HBVDNA for pregnant women with HBsAg (+), HBsAg was injected monthly from 16 to 20 weeks and terminated by elective cesarean section. HBVM was detected in newborns and combined with HBIG and hepatitis B vaccination. The positive rate of HBVDNA in maternal milk was detected Use artificial feeding of babies. Results There were 256 58 pregnant women and 318 HBsAg positive patients (12 38%). Neonatal HBsAg (+) in 10 cases, accounting for 14.4%, newborns at 1 month retest without additional cases, a variety of measures combined blocking success rate of 96.86%. Conclusion Pregnant women early detection of HBVM, HBVDNA, early diagnosis, early treatment, a variety of interventions can effectively block the mother-to-child transmission of hepatitis B virus