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目的:评价在常规治疗上采用大承气汤与血必净治疗脓毒血症的有效性和安全性。方法:将26例脓毒血症的患者随机分为两组,每组13例。治疗组在常规抗感染、液体疗法、循环支持、保护胃黏膜、抗凝对症治疗及常规营养支持治疗,如病情需要给予脏器代替治疗,包括呼吸机和血液透析等,同时采用中药通里攻下之大承气汤口服或灌肠,每日1～2次;至肛门通畅排便排气时止。活血化瘀之血必净静脉滴注1次50ml/8小时,待血象、体温下降之后逐渐停药。对照组只行常规治疗。结果:治疗组的病死率15%,对照组为38%,两组病死率比较,差异有显著性(P<0.05)。结论:加用大承气汤和血必净可明显降低脓毒血症患者的病死率,提高临床疗效。
Objective: To evaluate the efficacy and safety of Dachengqi Decoction and Xuebijing in the treatment of sepsis. Methods: Twenty-six patients with sepsis were randomly divided into two groups (n = 13 in each group). The treatment group in the conventional anti-infective, fluid therapy, circulatory support, protection of gastric mucosa, anticoagulant symptomatic treatment and routine nutritional support treatment, such as the disease need to be given organs instead of treatment, including ventilator and hemodialysis, etc., Under the big Chengqi Tang oral or enema, 1 to 2 times a day; to the anus when the defecation exhaust only. Blood circulation of blood must be a net intravenous infusion of 50ml / 8 hours, to be blood, gradually decreased after the temperature dropped. Control group only conventional treatment. Results: The case fatality rate was 15% in the treatment group and 38% in the control group. There was significant difference between the two groups in the case fatality rate (P <0.05). Conclusion: The addition of Dachengqi Decoction and Xuebijing can significantly reduce the mortality of patients with sepsis and improve clinical efficacy.