论文部分内容阅读
中毒性损伤、病毒感染、自身免疫或遗传性疾病均可导致肝功能异常,继而引起慢性肝病或导致急性肝功能衰竭。肝脏移植目前仍是治疗急性肝功能衰竭和终末期肝病最有效的方法。但由于肝源的短缺及高昂的医疗费用,肝移植并非适合每个患者。另一方面,施行肝移植后患者可能出现排异、原发疾病的复发及免疫抑制剂的副作用等。因此,有必要发展一种可取代传统肝移植的治疗方法。肝细胞移植和生物人工肝被认为是有前途的方法。在过去20年里,干细胞因其自身具有自我更新及多向分化能力而受到广泛关注。
Toxic injuries, viral infections, autoimmune or genetic disorders can lead to abnormal liver function, which in turn can lead to chronic liver disease or lead to acute liver failure. Liver transplantation is still the most effective treatment of acute liver failure and end-stage liver disease. However, due to the shortage of liver and high medical costs, liver transplantation is not suitable for each patient. On the other hand, patients may experience rejection after liver transplantation, recurrence of primary disease and side effects of immunosuppressive agents. Therefore, it is necessary to develop a treatment that can replace traditional liver transplantation. Hepatocyte transplantation and bioartificial liver are considered as promising methods. For the past two decades, stem cells have drawn much attention due to their ability to self-renew and multiply differentiate.