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目的:探讨Derlin-1在结肠癌中的表达,评估其与结肠癌患者临床病理学特征的相关性。方法:免疫组织化学方法检测Derlin-1在90例结肠癌组织及其相应的癌旁正常组织中的表达,并分析Derlin-1与临床病理学特征的关系。结果:与癌旁正常组织相比,结肠癌组织Derlin-1的表达显著增加(70%,P<0.001);Derlin-1表达水平与结肠癌组织分化程度、浸润深度、淋巴结转移、远处转移、Dukes分期显著相关。结论:Derlin-1在结肠癌高表达,且与结肠癌患者的临床病理学特征高度相关,可作为结肠癌的监测指标。
OBJECTIVE: To investigate the expression of Derlin-1 in colon cancer and to evaluate its correlation with the clinicopathological characteristics of patients with colon cancer. Methods: Immunohistochemistry was used to detect the expression of Derlin-1 in 90 cases of colorectal cancer tissues and corresponding normal tissues. The relationship between Derlin-1 and clinical pathological features was analyzed. Results: The expression of Derlin-1 was significantly increased in colorectal cancer tissues compared with that in adjacent normal tissues (70%, P <0.001). The expression of Derlin-1 was correlated with the differentiation degree, depth of invasion, lymph node metastasis and distant metastasis Dukes staging was significantly correlated. Conclusion: Derlin-1 is highly expressed in colon cancer and is highly correlated with the clinicopathological features of colon cancer patients. It may be used as a marker for colon cancer.