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目的 : 研究抗孕唑 (DL111 IT)对中枢、传出神经、呼吸及心血管系统的作用。方法 :采用小鼠睡眠时间、惊厥反应、刻板运动试验和家兔大脑皮层电图描记法 ,观察中枢神经系统作用 ;用乌拉坦麻醉猫观察血压、呼吸、心电图的变化 ;以受体效应为指标 ,观察传出神经系统功能。结果 :在抗早孕剂量范围 ,DL111 IT对小鼠有镇静作用 ;对家兔大脑皮层电图及麻醉猫的血压、呼吸、心电图无明显影响 ;对传出神经系统功能亦无效应。结论 :DL111 IT对中枢神经系统有一定镇静作用 ;对呼吸、心血管及传出神经系统无明显影响
Objective: To study the effect of DL111 IT on central nervous system, respiratory, cardiovascular and cardiovascular system. Methods: The effects of central nervous system (CNS) in mice were observed by sleep time, convulsion reaction, stereotypic exercise test and rabbit cortex electrogram. The urethane anesthesia was used to observe the changes of blood pressure, respiration and electrocardiogram. , Observe the outgoing nervous system function. Results: In the anti-early pregnancy dose range, DL111 IT had a sedative effect on mice; no significant effect on the cerebral cortex electrogram of anesthetized cats and blood pressure, respiration and electrocardiogram of anesthetized cats; and no effect on the afferent nervous system. Conclusion: DL111 IT has a certain sedative effect on the central nervous system; it has no obvious effect on the respiratory, cardiovascular and efferent nervous systems