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目的探讨胃癌癌旁组织发生萎缩性改变时HP感染阳性率和Ki-67增殖的相关性。方法31例经外科手术切除的胃癌石蜡包埋组织,进行切片、HE染色、特殊染色、免疫组化等。结果31例胃癌癌旁组织发生萎缩性改变的组织中,有14例HP阳性,有17例HP阴性;9例Ki-67阳性表达,有16例HP阳性表达,且9例Ki-67阳性表达者HP也为阳性。结论HP感染是慢性萎缩性胃炎和胃癌的一个重要致病因素;HP感染可促进胃上皮细胞的增殖;Ki-67是反映细胞增殖活性的指标;慢性萎缩性胃炎HP感染与Ki-67表达是正相关。
Objective To investigate the correlation between the positive rate of HP infection and the proliferation of Ki-67 in the paracancerous tissues of gastric cancer. Methods Twenty-one cases of gastric cancer paraffin-embedded tissues were excised. The sections were stained with HE staining, special staining and immunohistochemistry. Results Of the 31 cases with atrophic changes of gastric cancer adjacent tissues, 14 cases were positive for HP and 17 cases were negative for HP. 9 cases were positive for Ki-67, 16 cases were positive for HP and 9 cases were positive for Ki-67 HP is also positive. Conclusion HP infection is an important causative agent of chronic atrophic gastritis and gastric cancer. HP infection can promote the proliferation of gastric epithelial cells. Ki-67 is an indicator of cell proliferative activity. HP infection of chronic atrophic gastritis and Ki-67 expression are positive Related.