儿童和青春期垂体腺瘤的诊断和治疗

• 作 者: 骆纯 马驰原 卢亦成
• 机 构: 第二军医大学附属长征医院神经外科,第二军医大学附属长征医院神经外科,第二军医大学附属长征医院神经外科 上海200003,上海200003,上海200003
• 出 处: 中华神经医学杂志
• 发表日期: 2003年03期
• 关键词: 儿童 青春期 垂体腺瘤

儿童和青春期垂体腺瘤多数指16或18岁以前经手术证实的病例。全面评估内分泌、影像学改变是诊断的关键、治疗的基础。儿童和青春期PRL腺瘤与成人PRL腺瘤在对溴隐停有效性方面相同。甲介型或气化不良的蝶窦并不是经蝶手术的禁忌症。关于Cushing’s病的治疗,首选经蝶手术,治愈率可达80％～98％。放射治疗应严格掌握适应症,尽可能减少延迟性的垂体功能低下的发生。术后可以发生各种垂体和下丘脑功能障碍,长期、正规的随访具有特别重要的意义。

Most children and adolescent pituitary adenomas refer to cases that have been surgically confirmed before the age of 16 or 18 years. A comprehensive assessment of endocrine, imaging changes is the key to diagnosis, treatment basis. Child and adolescent PRL adenomas are identical to adult PRL adenomas in terms of effectiveness of exposure to bromine. A type or poor gasification sphenoid sinus surgery is not a contraindication. About Cushing’s disease treatment, the preferred transsphenoidal surgery, the cure rate of up to 80% to 98%. Radiation therapy should be strictly controlled indications, as far as possible to reduce the occurrence of delayed hypopituitarism. Postoperative can occur a variety of pituitary and hypothalamic dysfunction, long-term, regular follow-up is of special importance.