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在慢性阻塞性肺疾病(COPD)患者中难以从临床上把哮喘、慢性支气管炎(慢支)或肺气肿区分开,部分是因为原来的定义都是相互交叉的,如哮喘是从功能上确定,而肺气肿和慢支又分别从病理学和症状学解释,故常见符合上述3种定义的患者.对乙酰甲胆碱或组织胺的气道反应性增高,往往可见于慢性气流阻塞(CAO)和哮喘患者,故无助于诊断。然而,研究又证实两种病对较多天然刺激(如冷空气或气雾)的气道反应性不同,从此对哮喘和CAO 的发病机理产生了新的认识。
It is difficult to distinguish clinically from asthma, chronic bronchitis (chronic bronchitis) or emphysema in patients with chronic obstructive pulmonary disease (COPD), in part because the original definitions are all inter-related, as asthma is functionally Confirmed, and emphysema and chronic bronchitis, respectively, from the pathology and symptomology, so common in patients with the above three definitions of methacholine or histamine amine increased airway reactivity, often seen in chronic airway obstruction (CAO) and asthma patients, it does not help diagnosis. However, the study confirmed that the airway responsiveness of both diseases to more natural stimuli (such as cold air or aerosol) was different and led to a new understanding of the pathogenesis of asthma and CAO.