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目的:观察还原型谷胱甘肽治疗慢性病毒性肝炎合并酒精肝损伤的临床效果。方法:选择2016年6月-2017年8月期间在我院接受治疗的慢性病毒性肝炎合并酒精肝损伤患者56例作为研究对象,随机划入观察组和对照组,其中观察组28例,对照组28例,对照组患者接受常规护肝治疗,观察组在此基础上给予还原型谷胱甘肽,比较两组患者的肝功指标水平和治疗总有效率。结果:观察组患者ALT水平59.8±2.7IU/L,AST水平42.8±1.3IU/L,TBIL61.1±2.9IU/L,总有效率92.9%;对照组患者ALT水平98.5±2.3IU/L,AST水平96.5±1.5IU/L,TBIL85.5±2.4IU/L,总有效率71.4%;组间差异有统计学意义,P<0.05。结论:还原型谷胱甘肽治疗慢性病毒性肝炎合并酒精肝损伤疗效显著,患者肝功能指标显著改善,治疗有效率更高,值得临床应用和推广。
Objective: To observe the clinical effect of reduced glutathione on chronic viral hepatitis with alcoholic liver injury. Methods: Fifty-six patients with chronic viral hepatitis with alcohol-induced liver injury who were treated in our hospital from June 2016 to August 2017 were selected and randomly divided into observation group and control group, 28 cases in observation group and control group Twenty-eight patients in the control group received routine hepatoprotective therapy. The observation group was given glutathione on the basis of the same. The level of liver function and total effective rate were compared between the two groups. Results: The ALT level in the observation group was 59.8 ± 2.7 IU / L, the AST level was 42.8 ± 1.3 IU / L and the TBIL was 61.1 ± 2.9 IU / L, with a total effective rate of 92.9%. The ALT level in the control group was 98.5 ± 2.3 IU / L, AST level 96.5 ± 1.5IU / L, TBIL85.5 ± 2.4IU / L, the total effective rate 71.4%; There was significant difference between groups, P <0.05. Conclusion: Reduced glutathione treatment of chronic viral hepatitis with alcoholic liver injury significant effect, patients with significant improvement in liver function indicators, the treatment is more efficient and worthy of clinical application and promotion.