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目的：探讨恶性肿瘤骨转移时，其所造成的骨质损害与血清骨钙素水平的关系及临床应用价值。方法：通过核素全身骨显像扫描，将７０例恶性肿瘤患者分为骨转移组和非骨转移组，采用放射免疫分析方法对两组患者血清骨钙素水平检测分析。结果：骨转移组血清骨钙素水平显著高于非转移组（Ｐ＜０．００１）及正常对照组（Ｐ＜０．０２）；非转移组血清骨钙素水平与正常对照组比较，则显著降低（Ｐ＜０．００１）；骨转移病灶数目与血清骨钙素水平呈显著正相关（ｒ＝０．７０２，Ｐ＜０．００１）。结论：结果提示，当恶性肿瘤患者血清骨钙素水平呈增高趋势时，应警惕骨转移的发生。
Objective: To investigate the relationship between bone mineral damage caused by bone metastases and serum osteocalcin levels in malignant tumors and its clinical value. Methods: Seventy patients with malignant tumors were divided into bone metastasis group and non-bone metastasis group by radionuclide whole body bone scan. Serum osteocalcin levels were detected by radioimmunoassay. Results: Serum osteocalcin levels in bone metastasis group were significantly higher than those in non-metastatic group (P<0.001) and normal control group (P<0.02). Serum osteocalcin levels in non-metastatic group were compared with those in normal control group. Significantly decreased (P<0.001); there was a significant positive correlation between the number of bone metastatic lesions and serum osteocalcin levels (r=0.702, P<0.001). Conclusion: The results suggest that when the serum osteocalcin levels of patients with malignant tumors show an increasing trend, bone metastasis should be guarded against.