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内皮素(endothelin,ET)是新近发现的血管内皮细胞产生的生物活性多肽,是迄今所知体内最强的缩血管物质。经放免自显影技术发现,ET 广泛分布于心血管、肝、肾、脑及胃肠道内。早期对内皮素生物学效应的研究已表明,ET 可增加心脏的正性肌力作用,对绝大多数种属动物不同部位的动脉、静脉和微血管有极强的收缩作用,产生明显的升压反应。近年来国外对 ET 在胃肠损伤中的作用机制、病理生理改变进行了大量的动物实验研究,其结果表明:ET 对胃畅道血管平滑肌的调整
Endothelin (ET) is a recently discovered biologically active polypeptide produced by vascular endothelial cells and is by far the strongest vasoconstrictor substance in the body. After radioimmunoassay discovery technology, ET is widely distributed in cardiovascular, liver, kidney, brain and gastrointestinal tract. Early studies of the biological effects of endothelin have shown that ET increases the positive inotropic effect of the heart and has a profound contractile effect on arteries, veins and microvessels in different parts of most species of animals, reaction. In recent years, foreign countries on the role of ET in gastrointestinal injury mechanism, a large number of pathophysiological changes in animal studies, the results show that: ET on the regulation of gastrulation vascular smooth muscle