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本文观察了一组行滤过术的病人，以了解ＭＭＣ在青光眼滤过术后抗瘢痕形成的远期疗效．方法：原发性晚期青光眼 ５２例（６２只眼），其中开角型 １０例（１４ 只眼），慢性闭角型青光眼３６例（４０只眼）及以往行青光眼滤过术失败者 ６例（８只眼）． ＭＭＣ组（３２只眼），对照组（３０只眼）．在小梁切除术中一次使用含０．４ｍｇ／ｍｌＭＭＣ棉片置于球结膜／筋膜与巩膜间４分钟，对照组不使用ＭＭＣ．术后追踪观察１４个月（６个月～２４个月）．结果：功能性滤过泡ＭＭＣ组９６．８％，对照组６０．０％（Ｐ＜０．００５）； 手术成功率（ＩＯＰ≤２．８ｋＰａ，２１ｍｍＨｇ；不加用药物ＭＭＣ９３．７％，对照组２６．６％（Ｐ＜０．００５）。随机分为ＭＭＣ组低眼压性黄斑水肿５只眼、滤过泡渗漏１只眼，白内障１只眼，对照组未发现并发症。结论： ＭＭＣ具有明显抑制青光眼滤过术后瘢痕形成的作用，手术成功率明显提高，但术后可出现某些并发症。
This article looked at a group of patients who underwent filtration surgery to understand the long-term efficacy of MMC in preventing scarring after glaucoma filtration surgery. Methods: Fifty-two cases (62 eyes) of primary advanced glaucoma, including 10 cases of open angle (14 eyes), 36 eyes of chronic angle-closure glaucoma (40 eyes) and 6 cases of previous glaucoma filtering failure (8 eyes). MMC group (32 eyes), control group (30 eyes). In the trabeculectomy with 0.4mg / mlMCMC cotton placed in the conjunctiva / fascia and sclera 4 minutes, the control group did not use MMC. Follow-up observation of 14 months (6 months to 24 months). Results: The functional filtering bleb MMC group was 96.8%, the control group 60.0% (P <0.005); The success rate of operation (IOP≤2.8kPa, 21mmHg; without using drug MMC93.7%, control Group (26.6%, P <0.005) .All patients were randomly divided into five groups: hypofluorid macular edema in MMC group, one case of leaking bleb, one case of cataract, and no complication in control group.Conclusion : MMC has the effect of significantly inhibiting the formation of scar after glaucoma filtration surgery, the success rate of surgery increased significantly, but some complications may occur after surgery.