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目的观察制首乌总游离蒽醌在防治动脉粥样硬化过程中对ApoE~(-/-)小鼠肝脏、腹腔脂肪组织重量及血脂、血清NO含量的影响。方法将36只ApoE~(-/-)小鼠随机分为正常对照组、模型组、制首乌总游离蒽醌高、中、低剂量组,除正常对照组外,高脂饲料喂养建立动脉粥样硬化模型,造模时间为4周。4周后开始按浓度给药,正常对照组、模型组予生理盐水灌胃,给药时间为6周。给药结束后处死,开腹腔取肝脏称重记录,摘除腹腔其余脏器后剥离腹腔脂肪组织并称重记录。试剂盒测定各组小鼠血脂、血清NO含量。结果与模型组相比,制首乌总游离蒽醌能降低腹腔脂肪组织重量;与模型组相比,制首乌总游离蒽醌能降低血清中TG、TC含量,并能提高HDL-C含量,具有统计学意义(P<0.05);与模型组相比,制首乌总游离蒽醌中、高剂量组能提高血清NO含量。结论制首乌总游离蒽醌具有一定的抗动脉粥样硬化作用,该作用可能与其调节血脂、影响血清NO含量有关。
Objective To observe the effects of total anthraquinones of Radix Polygoni multiflori on the weight of liver and peritoneal adipose tissue and the content of serum lipids and serum NO in ApoE ~ (- / -) mice during the prevention and treatment of atherosclerosis. Methods Thirty-six ApoE ~ (- / -) mice were randomly divided into normal control group, model group, total anthraquinone free radicals in Radix Sophorae Preparata, medium and low dose groups, except the normal control group, Atherosclerosis model, modeling time of 4 weeks. After 4 weeks, the mice were dosed according to the concentration. Normal control group and model group were given normal saline intragastrically for 6 weeks. Sacrifice after the end of the administration, open the abdominal cavity to take the liver weight record, remove the remaining abdominal organs after stripping intraperitoneal adipose tissue and weighing records. Kits were used to determine the serum lipids and serum NO levels in each group. Results Compared with the model group, total anthraquinone from Radix notoginseng decreased the weight of abdominal fat tissue. Compared with the model group, total anthraquinone from Radix notoginseng could reduce the content of TG and TC in serum and increase the content of HDL-C , With statistical significance (P <0.05). Compared with the model group, the total free anthraquinone of Radix Polygoni multiflori increased the serum NO content. Conclusion The total anthraquinone from Radix Polygoni multiflori has some anti-atherosclerotic effects, which may be related to the regulation of blood lipids and the serum NO content.