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目的:研究瑞舒伐他汀对颈动脉粥样硬化斑块的治疗效果。方法:将在本院接受治疗的250例颈动脉粥样硬化斑块患者随机分成治疗组125例和对照组125例,治疗组服用瑞舒伐他汀10mg/晚,对照组行其他非瑞舒伐他汀药物治疗,进行为期6个月的观察对比。结果:治疗组治疗后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)水平显著下降,高密度脂蛋白(HDL)水平显著升高(P<0.05),颈动脉内膜-中层厚度(IMT)、斑块面积变小,与治疗前比较,差异有统计学意义(P<0.05);对照组治疗前后无显著性差异(P>0.05)。结论:瑞舒伐他汀对降低血脂、减缓不稳定型心绞痛早期动脉粥样硬化、稳定斑块和预防脑血管疾病起到非常重要的作用。
Objective: To study the effect of rosuvastatin on carotid atherosclerotic plaque. Methods: 250 patients with carotid atherosclerosis treated in our hospital were randomly divided into treatment group (125 cases) and control group (125 cases). The treatment group received rosuvastatin (10 mg / night) and the control group Statin drug treatment, for a period of 6 months of observation and comparison. Results: The levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL), the level of high density lipoprotein (HDL) Membrane - middle thickness (IMT), plaque area became smaller, compared with before treatment, the difference was statistically significant (P <0.05); there was no significant difference in the control group before and after treatment (P> 0.05). Conclusion: Rosuvastatin plays a very important role in lowering blood fat, slowing the early atherosclerosis, stabilizing plaque and preventing cerebrovascular diseases of unstable angina pectoris.