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目的观察利胆汤联合西药治疗妊娠期肝内胆汁淤积综合征的临床疗效。方法将74例妊娠期肝内胆汁淤积综合征患者随机分为治疗组与对照组,每组37例。对照组予常规利胆、退黄、保肝西药口服,治疗组在对照组治疗措施基础上加用利胆汤。两组疗程均为14天,比较总胆汁酸、肝功能指标(TBIL、DBIL、IBIL、AST、ALT)水平的变化情况,并随访观察不良妊娠结局情况。结果1治疗前后组内比较,两组总胆汁酸、肝功能指标(TBIL、DBIL、IBIL、AST及ALT)水平差异有统计学意义(P<0.05);组间治疗后比较,总胆汁酸、肝功能指标(TBIL、DBIL、IBIL、AST及ALT)水平差异有统计学意义,治疗组优于对照组(P<0.05)。2对照组不良妊娠结局发生率为27.03%,治疗组为10.81%;两组不良妊娠结局发生率比较,差异有统计学意义(P<0.05)。结论利胆汤联合西药治疗妊娠期肝内胆汁淤积综合征,可有效改善患者肝脏损伤及妊娠结局。
Objective To observe the clinical effect of combining Lizhen Decoction and western medicine on intrahepatic cholestasis syndrome during pregnancy. Methods Seventy-four patients with intrahepatic cholestasis syndrome during pregnancy were randomly divided into treatment group and control group, with 37 cases in each group. The control group was given routine gallbladder, yellow retreat, liver protection western medicine oral treatment group in the control group based on the treatment of measures plus gallbladder soup. The duration of treatment was 14 days. The changes of total bile acid and liver function indexes (TBIL, DBIL, IBIL, AST, ALT) were compared. The adverse pregnancy outcomes were followed up. Results 1 The levels of total bile acid and liver function (TBIL, DBIL, IBIL, AST and ALT) in the two groups before and after treatment were significantly different (P <0.05). After treatment, the levels of total bile acid, The indexes of liver function (TBIL, DBIL, IBIL, AST and ALT) were significantly different in treatment group and control group (P <0.05). The incidence of adverse pregnancy outcomes was 27.03% in the control group and 10.81% in the treatment group. There was significant difference in the incidence of adverse pregnancy between the two groups (P <0.05). Conclusions Li Dan Tang combined with western medicine in the treatment of intrahepatic cholestasis syndrome during pregnancy can effectively improve the liver injury and pregnancy outcomes.