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目的:探讨补骨脂素抑制良性前列腺增生的作用机制。方法:补骨脂素作用雄性去势大鼠注射丙酸睾酮后的前列腺湿重、前列腺指数、PCNA指数及前列腺组织病理学改变。结果:实验组大鼠前列腺湿重、前列腺指数和PCNA指数均显著低于对照组。结论:补骨脂素能显著抑制模型大鼠的良性前列腺增生,其机制可能是通过降低前列腺细胞增殖而实现的。
Objective: To explore the mechanism of action of psoralen in inhibiting benign prostatic hyperplasia. METHODS: Prostate wet weight, prostate index, PCNA index, and histopathological changes in prostate glands were observed in male ovariectomized rats injected with testosterone propionate. Results: The prostatic wet weight, prostate index, and PCNA index were significantly lower in the experimental group than in the control group. CONCLUSIONS: Psoralen can significantly inhibit benign prostatic hyperplasia in model rats. The mechanism may be achieved by reducing prostate cell proliferation.