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Ｃ５ａ－Ｃ５ａＲ相互作用是急性肺损伤（ＡＬＩ）、急性呼吸窘迫综合征（ＡＲＤＳ）的重要病因之一。本研究从Ｃ５ａＲ结构与功能的关系出发，探讨了Ｃ５ａＲ亲水性基序和Ｂ细胞优势表位的结构特点，以此多肽为免疫原成功地获得了一株小鼠抗人Ｃ５ａＲ（９－３０）短肽单克隆
C5a-C5aR interaction is one of the important causes of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). In this study, based on the relationship between structure and function of C5aR, we discussed the structural features of the C5aR hydrophilic motif and the dominant epitopes of B cells. Using this peptide as an immunogen, we successfully obtained a mouse anti-human C5aR (9-30 ) Short peptide monoclonal