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目的:研究新疆维吾尔族慢性胃炎人群HLA DRB1*08等位基因与幽门螺杆菌感染的关系。方法:采用幽门螺杆菌分离培养技术检测慢性胃炎汉族36例,维吾尔族33例人群的幽门螺杆菌感染情况,并采用PCRSSP检测HLA-DRB1*08等位基因。结果:(1)新疆维吾尔族慢性胃炎人群H.pylori(Hp)阳性率为79%,高于汉族慢性胃炎人群(56%)(P<0.05)。(2)两组慢性胃炎人群Hp阳性组中HLA-DRB1*08等位基因频率在汉族为10.0%,在维吾尔族为15.4%,HLA-DRB1*08等位基因在汉族与维吾尔族慢性胃炎人群中检出频率无差异,维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与Hp感染无关(P>0.05)。结论:(1)维吾尔族Hp感染率高于汉族慢性胃炎人群(P<0.05)。(2)维吾尔族与汉族慢性胃炎人群中HLA DRB1*08等位基因与H.pylori感染率无关。
Objective: To investigate the relationship between HLA DRB1 * 08 allele and Helicobacter pylori infection in Uighur people with chronic gastritis. Methods: H. pylori infection was detected in 36 cases of chronic gastritis and 33 cases of Uygur in Helicobacter pylori isolates by PCR. The HLA-DRB1 * 08 alleles were detected by PCR-SPECT. Results: (1) The positive rate of H.pylori (Hp) in Xinjiang Uygur population with chronic gastritis was 79%, which was higher than that of Han people with chronic gastritis (56%) (P <0.05). (2) The frequency of HLA-DRB1 * 08 allele in Hp positive group was 10.0% in Han nationality and 15.4% in Uygur nationality in Han nationality and Uygur nationality population with chronic gastritis The frequency of HLA DRB1 * 08 was not related to Hp infection in Uighur and Han patients with chronic gastritis (P> 0.05). Conclusion: (1) The prevalence of Hp in Uyghur people is higher than that of Han people with chronic gastritis (P <0.05). (2) HLA DRB1 * 08 allele was unrelated to H.pylori infection in Uighur and Han nationality with chronic gastritis.