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根据旋毛虫生活史特点,按4个不同发育阶段给药的方法,观察了甲苯咪唑和吡喹酮对146只感染旋毛虫小鼠的疗效。甲苯咪唑50mg/kg×0天,脱囊期幼虫和成虫的减虫率,分别为100％及82.5％;50mg/kg×7天,侵袭期幼虫和成囊期幼虫的减虫率,分别为92.7％及99.6％。结果表明,甲苯咪唑对旋毛虫各期都有显著的杀虫效果。 吡喹酮600mg/kg×1天,对肠道内脱囊期幼虫及成虫无效;300mg/kg×3天灌胃和100mg/kg×3天肌注,对侵袭期幼虫及肌肉内成囊期幼虫也无效。
According to the characteristics of Trichinella life history, according to four different developmental stages of administration, the effect of mebendazole and praziquantel on 146 mice infected with Trichinella was observed. The worm reduction rates of mebendazole at 50mg / kg × 0 days were 100% and 82.5%, respectively. The worm reduction rates of larvae and larvae at 50mg / kg × 7 days were 92.7% and 99.6% respectively. The results showed that mebendazole had significant insecticidal effect on Trichinella spiralis. Praziquantel 600mg / kg × 1 day, intestinal enucleation of larvae and adults is not effective; 300mg / kg × 3 days intragastric administration and 100mg / kg × 3 days intramuscular injection of larvae and intramuscular larvae Also invalid.