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目的:探讨术前动脉灌注化疗在直肠癌治疗中的价值。方法:56例直肠癌患者随机分为2组,治疗组(28例)采用动脉灌注化疗,2周后行直肠癌根治术;对照组(28例)单纯实施直肠癌根治手术。结果:治疗组手术根治切除率96.4%,对照组82.1%,2组比较差异有统计学意义(P<0.05);治疗组保肛率(89.3%)高于对照组(67.9%)(P<0.05),局部复发率(7.1%)低于对照组(28.6%)(P<0.05),术后远处转移率(10.7%)与对照组(17.9%)比较差异无统计学意义(P>0.05);治疗组与对照组1,2,3年生存率分别为82.1%,67.9%,57.1%和64.3%,42.9%,32.1%,中位生存期别为42个月和29个月,2组比较差异均有统计学意义(P<0.05)。结论:术前动脉灌注化疗可提高直肠癌根治切除率、术后生存率及低位直肠癌保肛率,是一种有效的新辅助治疗措施。
Objective: To investigate the value of preoperative arterial infusion chemotherapy in the treatment of rectal cancer. Methods: Fifty-six patients with rectal cancer were randomly divided into two groups. The treatment group (28 cases) received intra-arterial infusion chemotherapy and the radical resection of rectal cancer was performed after 2 weeks. The control group (28 cases) received radical surgery alone. Results: The radical resection rate was 96.4% in the treatment group and 82.1% in the control group, with significant difference between the two groups (P <0.05). The anal sphincter preservation rate (89.3%) in the treatment group was significantly higher than that in the control group (67.9% 0.05). The recurrence rate (7.1%) was lower than that of the control group (28.6%) (P <0.05). There was no significant difference between the distant metastasis rate (10.7%) and the control group (17.9% 0.05). The 1, 2, 3-year survival rates of treatment group and control group were 82.1%, 67.9%, 57.1% and 64.3%, 42.9% and 32.1% respectively. The median survival time was 42 months and 29 months, The differences between the two groups were statistically significant (P <0.05). Conclusion: Preoperative arterial infusion chemotherapy can improve the radical resection rate of rectal cancer, postoperative survival rate and low anorectal rectal cancer rate, is an effective neoadjuvant treatment.