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为了探讨甲状腺乳头状癌的发生机制、寻找反映其生物学行为的肿瘤标志物。采用多聚酶链式反应－单链构象多态性分析法（ＰＣＲ－ＳＳＣＰ），检测２０例甲状腺乳头状癌及１０例正常甲状腺组织Ｎ－ｒａｓ基因第６１位密码子突变。以流式细胞技术定量分析肿瘤细胞ＤＮＡ含量...
To investigate the mechanism of thyroid papillary carcinoma and find tumor markers that reflect its biological behavior. Polymerase chain reaction-single strand conformation polymorphism analysis (PCR-SSCP) was used to detect mutations in the codon 61 of the N-ras gene in 20 cases of thyroid papillary carcinoma and 10 cases of normal thyroid tissue. Quantitative analysis of tumor cell DNA content by flow cytometry...