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目的:探讨冠心病(CHD)患者血浆N末端脑钠肽原(NT-proBNP)与大内皮素-1(B ig ET-1)水平的变化及其与心功能的关系。方法:采用酶联免疫吸附试验双抗体夹心法对136例CHD患者及55例健康对照者进行血浆NT-proBNP和B ig ET-1测定,同时以彩色多普勒超声心电动仪测定CHD患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF),并与血浆NT-proBNP和B ig ET-1水平进行相关性分析。结果:CHD患者血浆NT-proBNP和B ig ET-1水平均明显高于健康对照者(P<0.01),且不同心功能患者之间的血浆NT-proBNP和B ig ET-1含量亦存在显著性差异(P<0.01);CHD患者血浆NT-proBNP水平与LVEF、LVESD、LVEDD呈现良好的相关性(r分别为-0.63、+0.57和+0.61,P均<0.01),而血浆B igET-1水平与LVEF、LVESD、LVEDD的变化亦密切相关(r分别为-0.51、+0.46和+0.49,P均<0.01);血浆NT-proBNP和B ig ET-1水平呈正相关(r=+0.47,P<0.01)。结论:NT-proBNP和B ig ET-1可能参与了CHD及心功能损伤的病理生理过程,血浆NT-proBNP升高与B ig ET-1的变化呈正相关。
Objective: To investigate the changes of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) and endothelin-1 (B ig ET-1) in patients with coronary heart disease (CHD) Methods: The serum NT-proBNP and B ig ET-1 levels in 136 patients with CHD and 55 healthy controls were measured by enzyme-linked immunosorbent assay (ELISA) double antibody sandwich method. Meanwhile, the color Doppler echocardiography was used to measure the left (LVEDD), left ventricular end-systolic diameter (LVESD), and left ventricular ejection fraction (LVEF) were measured and compared with those of plasma NT-proBNP and B ig ET-1. Results: The plasma levels of NT-proBNP and B ig ET-1 in CHD patients were significantly higher than those in healthy controls (P <0.01), and there were significant differences in plasma NT-proBNP and B ig ET-1 levels between patients with different cardiac functions (P <0.01). There was a good correlation between plasma NT-proBNP levels and LVEF, LVESD and LVEDD in patients with CHD (r = -0.63, +0.57 and +0.61, respectively, P <0.01) 1 levels were also closely related to the changes of LVEF, LVESD and LVEDD (r = -0.51, +0.46 and +0.49, respectively, P <0.01); the levels of NT-proBNP and B ig ET- , P <0.01). Conclusion: NT-proBNP and B ig ET-1 may be involved in the pathophysiological process of CHD and cardiac dysfunction. The increase of plasma NT-proBNP is positively correlated with the change of B ig ET-1.