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化疗诱发的肢端红斑(CIAE)是新近报道的、由某些化疗药物诱发的一种特殊性局部皮肤反应。本文回顾了有关文献,并提出了肢端红斑的多种临床表现与不同的机理有关。5-FU、阿霉素,尤其是阿糖胞苷是最常见的致病药物,而羟基脲、氨甲喋呤、环磷酰胺和邻对滴滴滴等单独或联合应用则也有个别的报道。目前尚不知其确切的发病率,但某些报道为6%～42%。大多发生于成人。其发病似稍与剂量有关,而药物的高峰水平和总积累剂量才是决定性的。通常大剂量、短期化疗比小剂量输注反应发生更快、更严重。再次用致病药物又可复发,病因未
Chemotherapy-induced acral erythema (CIAE) is a newly reported, localized chemotherapeutic-specific skin reaction. This article reviews the literature and suggests that various clinical manifestations of acral erythematosus are associated with different mechanisms. 5-FU, doxorubicin and especially cytarabine are the most common causative agents, while there is also a separate report on the use of hydroxyurea, methotrexate, cyclophosphamide and ortho-droplet alone or in combination. The exact incidence is unknown, but some reports range from 6% to 42%. Mostly occur in adults. Its incidence seems a little dose-related, and the peak level of the drug and the total accumulated dose is decisive. Usually high-dose, short-term chemotherapy occurs faster and more serious than small doses. Again with pathogenic drugs can be relapsed, etiology