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Objective: We evaluated the relationship between the clinical management of level VI lymph node and neck lymph node micrometastases in follicular thyroid carcinoma. Methods: 326 negative neck lymph nodes of 68 cases with follicular thyroid carcinoma on routine pathology were examined by keratin-19 monoclonal antibody and S-P immunohisto- chemistry to confirm lymph node micrometastasis. Follow-up pathological and clinical documents were compared. Results: Forty-six neck lymph nodes showed positive micrometastasis among 326 negative neck lymph nodes including 4 lymph nodes in Level II (4/42), 5 lymph nodes in Level III (5/34), 5 lymph nodes in Level IV (5/49), 1 lymph node in Leve IV (1/17) and 31 lymph nodes in Level VI (31/184). Six in 14 cases with positive micrometastasis showed distant metastasis or local recurrence, but only 3 in 54 cases with negative micrometastasis indicated distant metastasis or local recurrence (P < 0.01). Conclusion: The research showed that Level VI neck lymph node micrometastasis is possibly occur and closely related with local recurrence and metastasis in follicular carcinoma of thyroid.
Objective: We evaluated the relationship between the clinical management of level VI lymph node and neck lymph node micrometastases in follicular thyroid carcinoma. Methods: 326 negative neck lymph nodes of 68 cases with follicular thyroid carcinoma on routine pathology were examined by keratin-19 monoclonal antibody and SP immunohisto- chemistry to confirm lymph node micrometastasis. Follow-up pathological and clinical documents were compared. Results: Forty-six neck lymph nodes showed positive micrometastasis among 326 negative neck lymph nodes including 4 lymph nodes in Level II (4/42) , 5 lymph nodes in Level III (5/34), 5 lymph nodes in Level IV (5/49), 1 lymph node in Leve IV (1/17) and 31 lymph nodes in Level VI (31/184). Six in 14 cases with positive micrometastasis for distant metastasis or local recurrence, but only 3 in 54 cases with negative micrometastasis for distant metastasis or local recurrence (P <0.01). Conclusion: The research showed that Level VI neck lym ph node micrometastasis is likely occur and closely related with local recurrence and metastasis in follicular carcinoma of thyroid.