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目的探讨肺癌患者血浆心钠素和内皮素在联合化疗前、后的动态变化及其在鉴别诊断与治疗中的临床价值。方法应用放射免疫法对82例肺癌患者在联合化疗前、化疗后34周内动态检测血浆心钠素和内皮素水平,并设正常对照组进行比较分析。结果小细胞肺癌患者血浆心钠素和内皮素与对照组比较无明显差异(P>0.05),而非小细胞肺癌组治疗前血浆心钠素和内皮素与对照组比较,治疗后与治疗前比较差异均有显著性意义(P<0.01)。结论血浆心钠素和内皮素动态检测预测肺癌患者对联合化疗的敏感性以及鉴别诊断有着重要的临床价值。
Objective To investigate the dynamic changes of plasma atrial natriuretic peptide and endothelin in patients with lung cancer before and after combined chemotherapy and their clinical value in the differential diagnosis and treatment. Methods Radioimmunoassay was used to detect the plasma levels of atrial natriuretic peptide and endothelin in 82 patients with lung cancer before and after chemotherapy. The normal control group was compared and analyzed. Results There was no significant difference in plasma atrial natriuretic peptide and endothelin between small cell lung cancer patients and control group (P> 0.05), while non-small cell lung cancer group before treatment, plasma atrial natriuretic peptide and endothelin compared with the control group, The differences were significant (P <0.01). Conclusion Dynamic detection of plasma atrial natriuretic peptide and endothelin has an important clinical value in predicting the sensitivity and differential diagnosis of lung cancer patients.