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目的了解HBsAg携带者的转归情况。方法对HBsAg携带者进行回顾性问卷调查和血清学检测,了解HBsAg携带者发生阴转及转化为乙型肝炎、肝硬化、肝癌甚至死亡的情况。结果对197名HBsAg携带者进行8年以上的回顾性调查,调查对象平均年龄46.2岁,回顾调查年限8~34年。在此期间2例发生HBsAg阴转;发生乙型肝炎33例、肝硬化9例,肝癌10例;死亡11例,其中9例死于肝癌,2例死于肝硬化;男性发生乙型肝炎、肝硬化和肝癌的男性比例(39/103)远远大于女性(13/94)(χ2=14.61,P<0.05)。结论HBsAg携带者发生阴转的机率较小,应定期进行体检。
Objective To understand the outcome of HBsAg carriers. Methods The HBsAg carriers were retrospectively surveyed and serologically tested to find out whether HBsAg carriers were overcast and converted to hepatitis B, cirrhosis, liver cancer and even death. Results A total of 197 HBsAg carriers were retrospectively surveyed for more than 8 years. The average age of the respondents was 46.2 years and the survey period was 8 to 34 years. During this period, 2 cases of HBsAg negative occurred; hepatitis B occurred in 33 cases, 9 cases of liver cirrhosis, liver cancer in 10 cases; 11 cases of death, of which 9 died of liver cancer, 2 died of cirrhosis; The proportion of men with cirrhosis and liver cancer (39/103) was significantly greater than that of women (13/94) (χ2 = 14.61, P <0.05). Conclusion HBsAg carriers are less likely to have a negative conversion, and should undergo regular medical examination.