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对哮喘11例患者和12名正常人进行支气管肺泡灌洗(BAL),两组BAL液中细胞总数和各细胞百分率包括肺泡巨噬细胞(AM)、淋巴细胞、嗜中性与嗜酸性粒细胞无显著差异。体外培养条件下,粉尘螨(DPF)抗原激发后,哮喘者AM释放前列腺素E(PGE)的量明显增加。哮喘者AM经DPF特异性IgE阳性血清致敏及DPF激发,释放PGE前列腺素F_(2a)(PGF_(2a))均较DPF特异性阴性血清及DPF激发组显著增加(P<0.01),PGE/PGF_(2a)比值明显下降,并与患者MCH-PC_(20)值明显正相关。结果表明,哮喘者AM在特异性IgE及抗原作用下释放PGE、PGF_(2a)量的不同,乃至PGE/PGF_(2a)比值下降对哮喘发病起重要作用。BAL用于稳定性哮喘患者较为安全。
Bronchoalveolar lavage (BAL) was performed on 11 asthmatic patients and 12 normal controls. The total number of BAL cells and the percentages of all the cells in the two groups were alveolar macrophages (AMs), lymphocytes, neutrophils and eosinophils No significant difference. In vitro, the amount of prostaglandin E (PGE) released by AM significantly increased after challenge with dust mite (DPF) antigen. Compared with DPF-specific negative serum and DPF-stimulated group, the AM of AMI patients sensitized by DPF-specific IgE-positive serum and DPF-induced PMF release (PGF_ (2a) / PGF_ (2a) ratio decreased significantly, and with the patient MCH-PC_ (20) value was significantly positive correlation. The results showed that the release of PGE by AM with specific IgE and antigens, the difference of the amount of PGF_ (2a), and even the decrease of PGE / PGF_ (2a) ratio play an important role in the pathogenesis of asthma. BAL is safer for patients with stable asthma.