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目的探讨颈动脉粥样硬化(CAS)患者基质金属蛋白酶(MMP)-9水平、颈动脉斑块及其与人巨细胞病毒(HCMV)感染的相关性。方法对90例CAS患者的HCMV-PP65抗原、血清MMP-9水平和颈动脉彩色多普勒超声检测结果进行分析和比较。结果(1)HCMV阳性(A组)、HCMV阴性(B组)及正常对照者(C组)血清MMP-9含量分别为(260.25±89.03)pg/ml、(157.47±78.28)pg/ml、(138.65±80.73)pg/ml,A组显著高于B组与C组(均P<0.01);B组及C组间差异无统计学意义。(2)A组颈动脉不稳定斑块检出率为81.25%(39/48),软斑积分为(2.905±0.768)分,显著高于B组[59.52%(25/42),(1.750±0.463)分](均P<0.05);A组硬斑积分[(2.273±0.647)分]与B组[(2.364±0.658)分]比较差异无统计学意义。结论CAS伴HCMV-PP65抗原阳性患者血清MMP-9水平明显增高,CAS斑块检出率高,且更具不稳定性。
Objective To investigate the relationship between the levels of matrix metalloproteinase (MMP) -9 and carotid plaque in human beings with carotid atherosclerosis (CAS) and their association with human cytomegalovirus (HCMV) infection. Methods The HCMV-PP65 antigen, serum MMP-9 levels and carotid color Doppler ultrasound in 90 CAS patients were analyzed and compared. Results The serum levels of MMP-9 in HCMV positive group (A group), HCMV negative group (B group) and normal control group (C group) were 260.25 ± 89.03 pg / ml and 157.47 ± 78.28 pg / (138.65 ± 80.73) pg / ml in group A, which was significantly higher in group A than in group B and C (all P <0.01). There was no significant difference between group B and group C (2) The detection rate of instability plaque in group A was 81.25% (39/48) and the score of soft plaque was (2.905 ± 0.768) points, which was significantly higher than that in group B [59.52% (25/42), (1.750 ± 0.463), respectively (all P <0.05). There was no significant difference between group A and group B (2.364 ± 0.658). Conclusion The serum level of MMP-9 in CAS patients with positive HCMV-PP65 antigen is significantly higher, and the detection rate of CAS plaque is higher and more unstable.