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目的 探讨支气管上皮 -肌上皮瘤的病理组织学特点、诊断及鉴别诊断。方法 应用光镜、免疫组化染色及电镜等方法对 1例支气管上皮 -肌上皮瘤的手术切除标本进行组织学观察。结果 支气管上皮 -肌上皮瘤组织学特点为肿瘤细胞的多样化。免疫组化染色显示cytokeratin、S 10 0蛋白、Vimentin、MSA(muscle specialactin)等不同程度的阳性反应。电镜下显示瘤细胞胞浆内大量的肌微丝或微丝及不规则分布的致密体。细胞周围连续或中断的基板等。结论 支气管上皮 -肌上皮瘤是一种罕见的肿瘤 ,根据组织学特点 ,结合免疫组化染色及电镜下特征 ,可以作出明确的病理诊断
Objective To investigate the histopathological features, diagnosis and differential diagnosis of bronchial epithelial-myoepithelial neoplasia. Methods One case of bronchial epithelial-myoepithelial neoplasia was examined histologically by light microscopy, immunohistochemical staining and electron microscopy. Results The histological features of bronchial epithelial-muscular epithelial tumors were the diversification of tumor cells. Immunohistochemical staining showed positive responses of cytokeratin, S 10 0 protein, Vimentin, and MSA (muscle specialactin) to varying degrees. Under the electron microscope, a large number of myofilaments or microfilaments and irregularly distributed dense bodies in the cytoplasm of tumor cells were shown. Continuous or interrupted substrates around the cells. Conclusion Bronchial epithelial-myoepithelial neoplasia is a rare tumor. According to histological features combined with immunohistochemical staining and electron microscopy features, a clear pathological diagnosis can be made.