Synthesis and Absolute Configuration of (2S,3S,3aS,6S,7aR)-2,3-Dihydroxy-2-((R)-1-hydroxy-3-methylbu

• 作 者: 李东伟 左鸿华 胡敏 张娇燕 陈雷 黄年玉
• 机 构: Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmac
• 出 处: 结构化学
• 发表日期: 2017年08期
• 关键词: Configuration absolute monoclinic solids filtered spectrometer silica acetate po

To investigate the anti-ulcer effect of bisabolangelone reduction derivatives, the sesquiterpene was further proceeded with dihydroxylation reaction. The structure of the target compound was characterized by IR, ESI-MS, 2D NMR and elemental analysis, and its absolute configuration was confirmed with a Flack parameter of 0.08(16) by X-ray crystallography using a Cu radiation source. Compound(3), C_(15)H_(26)O_5, crystal data: monoclinic system, space group P2_1, a = 11.467(2), b = 6.0303(12), c = 11.711(2) ?, β = 99.70(3)°, V = 798.3(3) ?~3, Z = 2, F(000) = 312, D_c = 1.191 g/cm~3, μ = 0.723 mm~(-1), R = 0.0303 and wR = 0.0797 for 2590 independent reflections(Rint = 0.0164) and 2563 observed ones(I > 2σ(I)).

To investigate the anti-ulcer effect of bisabolangelone reduction derivatives, the sesquiterpene was further proceeded with dihydroxylation reaction. The structure of the target compound was characterized by IR, ESI-MS, 2D NMR and elemental analysis, and its absolute configuration was confirmed with a Flack parameter of 0.08 (16) by X-ray crystallography using a Cu radiation source. Compound (3), C 15 H 26 O 5, crystal data: monoclinic system, space group P2_1, a = 11.467 B = 6.0303 (12), c = 11.711 (2), β = 99.70 (3) °, V = 798.3 (3) Å ~ 3, Z = 2, F (000) = 312, D_c = 1.191 g / cm ~ 3, μ = 0.723 mm -1, R = 0.0303 and wR = 0.0797 for 2590 independent reflections (Rint = 0.0164) and 2563 observed ones (I> 2σ (I)).