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目的:分析前列地尔所致不良反应的特点与规律。方法:收集我院近几年来前列地尔所致不良反应事件,回顾患者临床资料,分析不良反应的特点,并探究其规律。结果:男性发生不良反应高于女性,中老年患者为高危人群;用药过程中,前3d为药物不良反应发生高峰期;前列地尔静脉滴注方式是导致不良反应主要途径;以单一用药导致不良反应为主;患者主要表现为循环系统、神经系统、皮肤及其附件、消化系统及免疫系统不良反应,患者经相应处理治愈12例,好转48例。结论:前列地尔所致不良反应较高,好发于中老年人,应重点关注老年患者用药情况,及早发现异常情况,及时处理,保证患者用药安全。
Objective: To analyze the characteristics and rules of alprostadil-induced adverse reactions. Methods: We collected the adverse reaction events caused by alprostadil in our hospital in recent years, reviewed the clinical data, analyzed the characteristics of adverse reactions, and explored its regularity. Results: Adverse reactions were higher in males than in females and middle-aged and elderly patients were at high risk. In the course of medication, the first three days showed the peak of adverse drug reactions. Alprostadil was the main cause of adverse reactions. Reaction mainly; patients mainly manifested as circulatory system, nervous system, skin and its accessories, digestive system and immune system adverse reactions. The patients were cured by the corresponding treatment in 12 cases, improvement in 48 cases. Conclusion: Alprostadil is associated with higher adverse reactions and predisposes to middle-aged and elderly patients. We should pay more attention to the use of drugs in elderly patients, detect abnormalities as soon as possible, and handle them promptly to ensure the safety of patients.