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目的:分析苏州大学附属儿童医院患儿万古霉素的临床使用情况及其合理性。方法:统计2012年12月—2013年3月间33例住院患儿36例次万古霉素的用法与使用时间,以及抗感染药物联用情况、病原学检查、药敏试验、用药前后的肝肾功能、药品不良反应(ADR)等情况进行分析。结果:33例患儿中,血液科为26例次(78.79%),联合用药为32例次(88.88%);经病原菌培养者为31例(93.94%),药敏试验者为7例(21.21%),而血药浓度监测例数为0。结论:临床应用万古霉素应严格按用药指征,并结合病原学检查结果合理选用,并制订个体化给药方案,加强血药浓度监测。
Objective: To analyze the clinical use of vancomycin in children’s hospital affiliated to Soochow University and its rationality. Methods: The usage and duration of 36 cases of vancomycin in 33 children hospitalized from December 2012 to March 2013 were analyzed, and the combination of anti-infectives, etiological examination, drug susceptibility test, liver before and after treatment Renal function, adverse drug reactions (ADR) and other conditions were analyzed. Results: Among the 33 children, hematology was found in 26 cases (78.79%), in combination with drugs in 32 cases (88.88%), in 31 cases (93.94%) in pathogen culture and in 7 cases 21.21%), while the number of blood drug concentration monitoring was 0. Conclusion: The clinical application of vancomycin should be strictly according to drug indications, combined with the etiological examination results of rational selection, and to develop individualized drug delivery programs to strengthen blood drug concentration monitoring.