论文部分内容阅读
目的 比较不同放疗方法治疗食管癌的临床近期疗效 ,及探讨内外照射组合治疗食管癌时的最优剂量组合。方法 回顾性分析两种不同放疗方法治疗的食管癌 92例 ,其中60 钴γ线外照射 32例 ,60 钴γ线外照射结合192 铱腔内照射 60例 ,比较两组的临床近期疗效 ,并对内外结合放疗组的不同放射剂量和放射反应进行分析。结果 外放疗加内放疗组的临床有效率为 80 % (CR +PR) ,放射反应 :重度 +中度为 30 % ,单纯外照射组则分别为 4 3.8% (P <0 .0 1)和 12 .3%。结论 60 钴γ线外照射结合192 铱腔内照射治疗食管癌的临床近期疗效优于单纯60 钴γ线外照射。加用腔内放疗时 ,放射反应明显增多且加重 ,解决方法为腔内治疗参考点累计剂量控制在 2 4 0 0cGY以内 ,并加大分割次数。外照射剂量宜选择 (5 5 0 0～ 60 0 0 )cGY/(5～ 6)w
Objective To compare the short-term efficacy of different radiotherapy methods for the treatment of esophageal cancer, and to investigate the optimal dose combination for internal and external radiation therapy for esophageal cancer. Methods 92 cases of esophageal cancer treated with two different radiotherapy methods were retrospectively analyzed. Among them, 32 cases received 60-cobalt gamma ray irradiation, 60 cases received cobalt-gamma γ-ray irradiation combined with 192 luminal irradiation, and 60 cases were compared. Clinical short-term efficacy was compared between the two groups. Different radiation doses and radiation responses were analyzed for both internal and external combined radiotherapy groups. Results The clinical effective rate of external radiotherapy plus internal radiotherapy group was 80% (CR +PR), radiological response: severe + moderate 30%, and external radiotherapy group was 4 3.8% (P < 0.01) and 12 .3%. Conclusion The clinical curative effect of 60 Coγ-irradiation combined with intracoronary irradiation of 192 铱 is better than 60 Coγ-irradiation alone. With the addition of intraluminal radiotherapy, the radiological response is significantly increased and aggravated. The solution is to control the cumulative dose of the endovascular treatment reference point within 2400 cGy, and increase the number of segmentation. The external radiation dose should be selected (5500-60000)cGY/(5-6)w