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对31例正常人,11例成年型糖尿病患者及59例不同程度(轻、中、重度)耐糖量减低者负荷糖后胰岛素的分泌及血糖、血脂以及血浆cAMP的改变进行了分析。结果发现,耐糖量降低者,胰岛素的分泌有不同程度增加,峰值有不同程度之延后,胰岛素面积/血糖面积比值有不同程度之增加,而糖尿病组则未见明显之峰值,比值反较正常降低52.3％。血脂除HDL-胆固醇下降外,均较正常明显升高(P<0.001)。中度及重度耐糖降低组空腹血浆cAMP含量分别较正常降低30.3％及38.9％(P<0.05),而糖尿病组与正常组比较无差异。负荷糖后,糖尿病组cAMP含量不仅不下降,3小时后反较正常组升高63.4％(P<0.05)。对所得结果进行了讨论。
The changes of insulin secretion, blood glucose, blood lipid and plasma cAMP in 31 normal subjects, 11 adult diabetic patients and 59 patients with moderate to severe hypoglycemic glucose tolerance were analyzed. The results showed that those who had lower glucose tolerance and insulin had different degrees of increase, the peak delayed to some extent, the ratio of insulin area to blood glucose increased to some extent, but no obvious peak in diabetes mellitus, the ratio was normal Reduce by 52.3%. Except for HDL-cholesterol, serum lipids were significantly higher than normal (P <0.001). The levels of fasting plasma cAMP in moderate and severe glycemic control group were 30.3% and 38.9% lower than those in normal control group (P <0.05), but there was no difference between diabetic group and normal group. After loading sugar, the cAMP content in diabetic group not only did not decrease, but increased 63.4% after 3 hours (P <0.05). The results were discussed.