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微球制剂是药物和其它活性成份分散于蛋白、明胶、聚合物等材料中,经固化而成的固体球形颗粒载体制剂。因对特定器官组织具有靶向性,在肝癌、肾癌等化疗中疗效显著,深受重视。在微球研究中发现药物突释是一个重要问题。人们对制备微球的方法,产生突释的原因,如何减少或消除突释、控制药物释放、靶向定位吸收、载体材料的性质、微球包载药物的性质以及制备技术对控释的影响等方面进行了大量
Microsphere preparation is a solid spherical granular carrier preparation which is solidified by dispersing drugs and other active components in materials such as protein, gelatin, polymer and the like. Because of the specific organ tissue targeting, in liver cancer, kidney cancer and other chemotherapy significant effect, by the attention. Drug burst discovery in microsphere research is an important issue. How to make the method of preparing microspheres, how to make the burst, how to reduce or eliminate the burst, how to control the drug release, the orientation and absorption, the nature of the carrier material, the nature of the microsphere-encapsulated drug and the influence of preparation technology on controlled release And so on a lot