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氟苯桂嗪(flunarizine,氟脑嗪)是一种双氟哌嗪类衍生物,世界卫生组织(WHO)分类属第Ⅳ类钙通道阻滞剂。该药通过选择性抑制脑血管平滑肌细胞和脑神经细胞钙离子过度内流,而扩张脑血管,改善脑缺血、缺氧。随着对氟苯桂嗪药理学研究的深入,其应用日趋增多,现就其临床应用介绍如下。治疗急性脑血栓形成氟苯桂嗪对脑血管的扩张作用比对冠状动脉及肠系膜动脉的扩张作用强,在不致引起全身血压下降的剂量时即可增加脑血流量。王一尘等比较氟苯桂嗪和藻酸双酯钠治疗急性脑血
Flunarizine (flunarizine, flunarizine) is a derivative of diketopiperazines, and the World Health Organization (WHO) is classified as a type IV calcium channel blocker. The drug through selective inhibition of cerebrovascular smooth muscle cells and brain cells in the excessive calcium influx, and expansion of cerebral blood vessels, improve cerebral ischemia, hypoxia. With pfurodipine pharmacological research in-depth, its application is increasing, now its clinical application is as follows. Treatment of acute cerebral thrombosis Flunarizine on cerebrovascular expansion of coronary and mesenteric artery than the expansion of the role of strong, will not cause systemic blood pressure drops in the dose can increase cerebral blood flow. Wang Yichen and other more fluoride benzene azinine and sodium alginate in the treatment of acute cerebral hemorrhage