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目的研究呼吸道感染患儿病原学特点及血清肿瘤坏死因子(TNF-α)、C-反应蛋白(CRP)诊断运用,为临床治疗提供参考依据。方法选取医院2015年1月-2015年12月收治的544例呼吸道感染患儿,按照感染类型分为细菌感染组318例及非细菌感染组226例,并选择同期在医院健康检查的250名儿童为对照组,观察呼吸道感染患儿病原学特点及TNF-α、CRP的差异。结果感染组患儿共培养出446株病原菌,以革兰阴性菌为主,共281株占63.00%;细菌感染组血清中TNF-α及CRP水平高于非细菌感染组和对照组水平,差异有统计学意义(P<0.05)。结论导致患儿呼吸道感染的病原菌相对较多,且具有季节性特点,且细菌感染的患儿血清TNF-α及CRP水平显著升高,对诊疗具有重要指导意义。
Objective To study the etiological characteristics and serum levels of tumor necrosis factor (TNF-α) and C-reactive protein (CRP) in children with respiratory tract infection and to provide reference for clinical treatment. Methods 544 children with respiratory tract infection admitted from January 2015 to December 2015 in our hospital were divided into 318 cases of bacterial infection and 226 cases of non-bacterial infection according to the type of infection. 250 children who were hospitalized during the same period As control group, to observe the etiological characteristics of children with respiratory tract infection and TNF-α, CRP differences. Results A total of 446 strains of pathogens were co-cultivated in the infected group, of which, Gram-negative bacteria were the major pathogens, with a total of 281 strains accounting for 63.00%. The levels of TNF-α and CRP in the bacterial infection group were higher than those in the non-bacterial group and the control group There was statistical significance (P <0.05). Conclusion The pathogens causing respiratory tract infections in children are relatively more and have seasonal characteristics. The serum levels of TNF-α and CRP in children with bacterial infections are significantly increased, which is of great guiding significance for the diagnosis and treatment.