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以天然血管紧张素转化酶抑制剂(ACEI)I_5B_2,WF-10129为先导化合物,结合现有ACEI的结构特征,设计和合成了含缬-酪-酪(I_(1～4)和缬(丙)-酪(Ⅱ～6)肽类化合物。初步药理试验表明,Ⅱ类化合物
Taking the natural angiotensin converting enzyme inhibitors (ACEI) I_5B_2 and WF-10129 as the lead compounds and combining with the structural characteristics of the existing ACEIs, the effects of valsartan - I_ (1-4) and valine ) - Cheese (Ⅱ ~ 6) Peptides Preliminary pharmacological tests show that the class Ⅱ compounds