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为观察CD3AK或肿瘤浸润的淋巴细胞(TIL)治疗晚期癌症的效果,对63例晚期癌症患者用效应细胞(CD3AK或TIL,总数15×109~5×109),联用白细胞介素2120万U~500万U,进行过继免疫治疗(AIT)。结果18例癌性胸水患者,治疗后14例有效,有效率778%;45例实体瘤患者经AIT治疗,4例部分缓解,11例肿瘤体积、小转移灶或肿大淋巴结有缩小变化。此外多数患者自觉症状和免疫功能也有明显改进和提高。认为AIT对某些晚期癌症治疗,可缩小肿瘤、提高免疫功能,如与其他疗法配合疗效更好。
To observe the efficacy of CD3AK or tumor-infiltrating lymphocytes (TIL) in the treatment of advanced cancer, 63 effector cells for advanced cancer patients (CD3AK or TIL, total number 15×109~5×109) were used together with interleukin 21.2 million U to 5 million U, adoptive immunotherapy (AIT). Results In 18 cases of cancerous pleural effusion, 14 cases were effective after treatment, with an effective rate of 77.8%; 45 cases of solid tumors were treated with AIT, 4 cases were partially relieved, and 11 cases had small changes in tumor volume, small metastases, or enlarged lymph nodes. . In addition, subjective symptoms and immune function were also significantly improved and improved in most patients. It is believed that AIT can reduce tumors and improve immune function for certain advanced cancer treatments, such as better efficacy with other therapies.