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目的 探讨 2型糖尿病患者血清瘦素水平与胰岛素水平等因素的相关性。方法 用放免法测定 2 0例肥胖 2型糖尿病患者和 2 0例非肥胖 2型糖尿病患者的血清瘦素 (LP)浓度、体重指数 (BMI)、空腹胰岛素 (FINS)、空腹血糖 (FPG)、血脂、血压、腰臀比 (WHR)等指标。结果 ⑴肥胖糖尿病组LP、FINS高于肥胖非糖尿病组 (P <0 0 5～ 0 0 1) ,而非肥胖糖尿病组LP、FINS与非肥胖非糖尿病组比较无显著性差异 (P >0 0 5 ) ;⑵无论糖尿病组或非糖尿病组肥胖者的LP显著性高于非肥胖者 (P <0 0 1) ,女性的LP平均为男性的 3 45倍 ;⑶LP与FINS、BMI、MBP、Tch、TG呈正相关 (P <0 0 5～ 0 0 0 0 ) ,与胰岛素敏感指数 (ISI)呈负相关 (P =0 0 0 1)。结论 肥胖 2型糖尿病存在明显的胰岛素抵抗及瘦素抵抗 ,非肥胖 2型糖尿病此种状态不明显 ;肥胖 2型糖尿病瘦素抵抗与胰岛素抵抗相关
Objective To investigate the correlation between serum leptin level and insulin level in type 2 diabetic patients. Methods The levels of serum leptin (LP), body mass index (BMI), fasting insulin (FINS), fasting blood glucose (FPG) and blood glucose were measured by radioimmunoassay in 20 obese patients with type 2 diabetes mellitus and 20 non-obese patients with type 2 diabetes mellitus Blood lipids, blood pressure, waist-hip ratio (WHR) and other indicators. Results (1) LP and FINS in obese diabetic group were higher than those in obese non-diabetic group (P <0.05-0.01), but there was no significant difference between non-obese diabetic group and non-obese non-diabetic group (P> 0 0 (P <0.01). LP in women was 345 times higher than that in men (P <0.01). (3) The correlation between LPL and FINS, BMI, MBP, Tch , TG (P <0.05 ~ 0.0000), but negatively correlated with insulin sensitivity index (ISI) (P = 0.00001). Conclusions There is obvious insulin resistance and leptin resistance in type 2 diabetes mellitus. The status of non-obese type 2 diabetes is not obvious. Leptin resistance in obese type 2 diabetes is related to insulin resistance