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肾间质纤维化(RIF)是多种肾脏疾病发展至终末期肾功能衰竭的共同通路,且肾间质纤维化程度与肾功能减退的相关性,比肾小球硬化与肾功能减退的相关性更为密切[1]。RIF是各种细胞、细胞因子、炎症介质等诸多因素相互作用,导致细胞外基质(ECM)代谢失衡,在间质异常积聚所致,因此细胞
Renal interstitial fibrosis (RIF) is a common pathway for the development of a variety of renal diseases to end-stage renal failure, and the correlation between the degree of renal interstitial fibrosis and renal dysfunction is more significant than that of glomerulosclerosis and renal dysfunction Sex is more closely [1]. RIF is a variety of cells, cytokines, inflammatory mediators and many other factors interact, leading to imbalance in the extracellular matrix (ECM) metabolism, abnormal accumulation in the interstitial cells, so the cells