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石棉肺系常伴有抗核抗体(ANA)的肺部病变之一。原发性肺纤维化、肺结核,矽肺以及慢性支气管炎等疾病均证实血液中有类风湿因子(RF)。曾报道石棉肺合并类风湿关节炎数例,但作者至今尚未见有全身性红斑狼疮(SLE)与石棉肺合并存在的报道。本文提示此种关联性与矽肺伴类风湿性关节炎即所谓“Caplan-Collinet”综合症有某种相似之处。本文报道,一例40岁男性病例(日吸香烟25支)。1975年11月,主诉全身关节酸痛,尤以肩关节最甚,数周内体重减轻6公斤,伴消耗热以及轻度呼吸困难。指端皮肤有溃疡,指间关节肿胀伴肌肉轻度萎缩。胸部X线片示弥散
Asbestos lungs are often associated with antinuclear antibodies (ANA) in one of the lung lesions. Primary pulmonary fibrosis, tuberculosis, silicosis and chronic bronchitis and other diseases have confirmed rheumatoid factor (RF) in the blood. A few cases of asbestosis and rheumatoid arthritis have been reported, but so far there are no reports of systemic lupus erythematosus (SLE) associated with asbestosis. This article suggests that there is some similarity between this association and silicosis with rheumatoid arthritis, the so-called “Caplan-Collinet syndrome.” This article reports a 40-year-old man with 25 cigarettes a day. November 1975, chief complaint of joint soreness, especially in the shoulder joint, weight loss of 6 kg in a few weeks, with consumption of heat and mild dyspnea. Finger skin ulcers, swollen fingers with mild muscle contraction. Chest X-ray showed diffuse