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目的研究辛伐他汀对家兔心肌梗死后(MI)心室重构及心功能的影响。方法家兔20只采用结扎冠状动脉左前降支的方法建立急性心肌梗死模型,随机分MI组(10只)和辛伐他汀组(10只)。MI组术后不给任何处理和干预,辛伐他汀干预组在MI术后3d口服辛伐他汀(10mg.kg-1.d-1)10周。术前和术后10周进行超声心动图检查。术后10周进行有创血液动力学测定,而后摘取心脏称重。取两组家兔左心室进行HE染色,做组织细胞学检查。结果10周后辛伐他汀组家兔左室重量、左室舒张期末径、左室收缩期末径、左房直径及左室舒张期末压显著低于MI组,射血分数、缩短分数明显高于MI组(P<0.05)。HE染色辛伐他汀组与MI组比较,心肌细胞变性坏死明显减轻,炎性细胞浸润减少,间质纤维化减轻,非梗死区心肌细胞的代偿性肥大增生较MI组为低。结论辛伐他汀能够改善心肌梗死后家兔心室重构和心功能。
Objective To study the effect of simvastatin on ventricular remodeling and cardiac function in rabbits after myocardial infarction (MI). Methods Twenty rabbits were randomly divided into MI group (n = 10) and simvastatin group (n = 10) by ligating left anterior descending coronary artery. MI group did not give any treatment and intervention after operation. Simvastatin intervention group was given simvastatin (10 mg.kg-1.d-1) for 10 weeks after MI. Echocardiography was performed preoperatively and 10 weeks after surgery. An invasive hemodynamic assay was performed 10 weeks after the procedure, and heart weighed. Take two groups of rabbits left ventricular HE staining, do cytology. Results In the simvastatin group, the left ventricular mass, the end diastolic dimension, the left ventricular systolic diameter, the left atrium diameter and the left ventricular end-diastolic pressure at 10 weeks in simvastatin group were significantly lower than those in MI group, and the ejection fraction and shortening fraction were significantly higher MI group (P <0.05). Compared with MI group, the number of myocardial cell degeneration and necrosis, the infiltration of inflammatory cells and the interstitial fibrosis in simvastatin group were significantly lower than those in MI group. The compensatory hypertrophy of cardiomyocytes in non-infarcted area was lower than that in MI group. Conclusion Simvastatin can improve ventricular remodeling and cardiac function in rabbits after myocardial infarction.