Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation

• 作 者: Qiu-Ming Wang Jian-Ling Du Zhi
• 机 构: DepartmentofGastroenterology,DepartmentofEndocrinology
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2013年19期
• 关键词: HEME oxygenase-1 HEPCIDIN Iron accumulation Oxidative stress Portal vein pressur
• 基金项目: Supported by Grants from the National Natural Science Foun-dation of China,No. 30970886,The Science and Technology Project of Dalian,No. 2010E15SF179,the Initial Doctoral funding of Liaoning Province,

AIM:To investigate the effects of the heme oxygenase(HO)-1/carbon monoxide system on iron deposition and portal pressure in rats with hepatic fibrosis induced by bile duct ligation(BDL).METHODS:Male Sprague-Dawley rats were divided randomly into a Sham gr